Module 1 — General Principles of Pharmacology · Course 4 of 5
Role in Module 1: explores relevant variability and individual information, such as genetic results and measured drug concentrations. Recommended after Pharmacodynamics. You can reopen any lesson at any time — your Quick Recall results show which concepts to revisit.
Pharmacogenomics and Therapeutic Drug Monitoring explain how genetic variation and measured drug concentrations help individualize therapy, improve treatment response, and reduce toxicity.
Course Content
01. Introduction to Individualized Therapy and Precision Pharmacology
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02. Why Patients Respond Differently
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03. PK Variability vs PD Variability
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04. Clinical Reasoning Framework for Individualized Therapy
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05. Basic Human Genetics for Clinical Pharmacology
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06. Genotype, Diplotype, Haplotype, and Phenotype
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Quick Recall Check 1: Individualized Therapy and PGx Foundations
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07. Functional Variation: Loss, Gain, and Altered Function
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08. Metabolizer Phenotypes
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09. Pharmacogenomics in Pharmacokinetics
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10. Pharmacogenomics and Precision Pharmacodynamics
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11. CYP Examples That Change Prescribing
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12. Transporter, Enzyme, and Toxicity PGx Beyond CYP
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Quick Recall Check 2: Functional Variation and PGx Prescribing
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13. HLA-Associated Toxicity and Immune Risk
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14. When PGx Changes Prescribing Decisions
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15. Interpreting Pharmacogenomic Reports
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16. Limitations: Avoiding Genetic Determinism
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Quick Recall Check 3: Actionability, HLA, and Clinical Decisions
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17. Therapeutic Drug Monitoring: Why Measure Concentrations?
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18. Therapeutic Window, Target Concentration, and Clinical Endpoint
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19. TDM Sampling: Timing Is Everything
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20. Free vs Total Concentrations and Protein Binding
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Quick Recall Check 4: Therapeutic Drug Monitoring Fundamentals
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21. TDM Calculations and Dose Revision
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22. Nonlinear PK and High-Risk TDM
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23. Modern TDM: AUC and Bayesian Dosing
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24. Precision Dosing Algorithm: Integrating PGx and TDM
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Quick Recall Check 5: Precision Dosing and PGx/TDM Integration
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Course Recall: Comprehensive Theory & Reasoning Assessment
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Clinical Application & Mastery Assessment
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