Pharmacodynamics

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Module 1 — General Principles of Pharmacology · Course 3 of 5

Role in Module 1: connects exposure and drug–target interactions with effects and response. Recommended after Pharmacokinetics. You can reopen any lesson at any time — your Quick Recall results show which concepts to revisit.

Pharmacodynamics

Pharmacodynamics explains how drug concentration produces clinical response, including receptor interactions, dose–response relationships, therapeutic benefits, and adverse effects.

Course Content

01. Pharmacodynamics: Drug Action at the Bedside
02. The Pharmacodynamic Chain
03. Pharmacodynamics vs Pharmacokinetics
04. Drug Targets Are Not Only Receptors
05. Selectivity, Specificity, and Polypharmacology
06. Binding Kinetics and Target Occupancy
07. Binding Affinity
08. Residence Time and Duration of Action
Quick Recall Check 1: Foundations and exposure
09. Event-Driven Pharmacology
10. Four Major Receptor Families
11. Ligand-Gated Ion Channels
12. GPCR Signaling and Amplification
13. Gs, Gi, and Gq G-Protein Coupled Signaling Pathways
14. Enzyme-Linked Receptors
15. Intracellular Receptors
16. Biased Agonism
17. Biologics and Monoclonal Antibodies
Quick Recall Check 2: Receptor families and signaling
18. Graded Concentration–Response Curves
19. Potency vs Efficacy
20. EC50, Hill Slope, and Cooperativity
21. Two-State Receptor Model
22. Agonist Classes
23. Partial Agonists in Practice
24. Receptor Reserve and Operational Efficacy
Quick Recall Check 3: Response curves and agonism
25. Map of Antagonism
26. Competitive Antagonism and Naloxone
27. Schild Analysis and pA2
28. Noncompetitive and Irreversible Antagonism
29. Targeted Covalent Inhibition
30. Allosteric Modulation
31. Physiologic and Chemical Antagonism
32. Drug Combinations: Additivity and Synergy
Quick Recall Check 4: Antagonism and combinations
33. Target Plasticity
34. Homologous vs Heterologous Desensitization
35. Tolerance, Tachyphylaxis, and Dependence
36. Up-Regulation, Rebound, and Withdrawal
37. Disease Changes Pharmacodynamics
38. Quantal Dose–Response Curves
39. Therapeutic Index and Safety Metrics
40. Monitoring: Concentrations, Biomarkers, Endpoints
41. Pharmacogenomics and Precision Pharmacodynamics
Quick Recall Check 5: Adaptation, disease, and safety
42. Clinical Prescribing Framework
43. Integrated Case: Inadequate Response
44. Final Synthesis
Foundations of Mastery: Comprehensive Final Assessment
Clinical Application & Mastery Assessment
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