Understand how diuretics alter nephron transport, fluid and electrolyte balance, and how those mechanisms guide clinical selection, dosing, toxicity prevention, and monitoring.
Course Content
01. Why Diuretics Matter
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02. Nephron Map: Site Determines Effect
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03. Pharmacokinetic Golden Rule
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04. Distal Sodium Delivery Explains Toxicity
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05. Carbonic Anhydrase Inhibitors
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06. SGLT2 Inhibitors and Tubuloglomerular Feedback
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07. Osmotic Diuretics: Mannitol
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08. Loop Diuretics: Mechanism
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09. Loop Diuretics: Hemodynamics and TGF
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10. Loop Diuretics: Uses and Toxicity
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11. Loop Pharmacokinetics and Dose Equivalence
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12. Thiazides: Mechanism
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13. Thiazides: Uses and Toxicity
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14. Mineralocorticoid Receptor Antagonists
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15. ENaC Blockers
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16. Vaptans: ADH Receptor Antagonists
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17. Sodium Correction Guardrails
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18. Calcium, Magnesium, and Uric Acid Rules
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19. Diuretic Resistance
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20. Syndrome-Based Drug Selection
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21. High-Yield Clinical Dosing Pearls
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22. Final Comparative Matrix
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